Hypertension is a common age-related disease, along with vascular and neurodegenerative diseases. Vascular ageing increases during hypertension, but hypertension itself accelerates vascular ageing, thus creating a vicious circle. Vascular stiffening, endothelial dysfunction, impaired contractility and vasorelaxation are the main alterations related to vascular ageing, as a consequence of vascular smooth muscle and endothelial cells senescence. Several molecular mechanisms have been involved into the functional and morphological changes of the aged vessels. Among them, oxidative stress, inflammation, extracellular matrix deregulation and mitochondrial dysfunction are the best characterized. In the present review, we discuss relevant literature about the biology of vascular and cerebrovascular ageing with a particular focus on mitochondria signalling. We underline the therapeutic strategies, able to improve mitochondrial health, which may represent a promising tool to decrease vascular dysfunction associated with ageing and hypertension-related complications.

Vascular ageing in hypertension. focus on mitochondria / Forte, Maurizio; Stanzione, Rosita; Cotugno, Maria; Bianchi, Franca; Marchitti, Simona; Rubattu, Speranza. - In: MECHANISMS OF AGEING AND DEVELOPMENT. - ISSN 0047-6374. - 189:(2020). [10.1016/j.mad.2020.111267]

Vascular ageing in hypertension. focus on mitochondria

Stanzione, Rosita
Methodology
;
Cotugno, Maria
Methodology
;
Marchitti, Simona
Methodology
;
Rubattu, Speranza
Supervision
2020

Abstract

Hypertension is a common age-related disease, along with vascular and neurodegenerative diseases. Vascular ageing increases during hypertension, but hypertension itself accelerates vascular ageing, thus creating a vicious circle. Vascular stiffening, endothelial dysfunction, impaired contractility and vasorelaxation are the main alterations related to vascular ageing, as a consequence of vascular smooth muscle and endothelial cells senescence. Several molecular mechanisms have been involved into the functional and morphological changes of the aged vessels. Among them, oxidative stress, inflammation, extracellular matrix deregulation and mitochondrial dysfunction are the best characterized. In the present review, we discuss relevant literature about the biology of vascular and cerebrovascular ageing with a particular focus on mitochondria signalling. We underline the therapeutic strategies, able to improve mitochondrial health, which may represent a promising tool to decrease vascular dysfunction associated with ageing and hypertension-related complications.
2020
ageing; cardiovascular diseases; hypertension; mitochondria; stroke
01 Pubblicazione su rivista::01a Articolo in rivista
Vascular ageing in hypertension. focus on mitochondria / Forte, Maurizio; Stanzione, Rosita; Cotugno, Maria; Bianchi, Franca; Marchitti, Simona; Rubattu, Speranza. - In: MECHANISMS OF AGEING AND DEVELOPMENT. - ISSN 0047-6374. - 189:(2020). [10.1016/j.mad.2020.111267]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1404890
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